Matthijs Constantijn Dorst, PhD.

Former editor for Nature Communications. Earlier: neuroscientist in the Silberberg lab at the Karolinska Institutet. Known for riding motorcycles, playing videogames and being an excessive zip-tie user. Forever in love with Josje. Basal ganglionist and patch-clamp electrophysiologist for my sins. Perpetually baffled.

In my research I combined multi-cell ex vivo patch clamp electrophysiology with chemogenetics, optogenetics and pharmacological manipulation to investigate the neural microcircuits of the Striatum. As editor, I primarily handled manuscripts on neurophysiology. Nothing quite like unravelling the secret wiring of the brain.

Occasionally drones on about neuroscience stuff on Twitch, with excerpts randomly appearing on Youtube.
My analysis tools are on , 3D printing designs on .


Dorst, M.C., Díaz-Moreno, M., Oliveira Dias, D., Guimarães, E. L., Holl, D., Kalkitsas, J., Silberberg, G. and Göritz, C. 2021. Astrocyte-derived neurons provide excitatory input to the adult striatal circuitry Proceedings of the National Academy of Sciences, 118(33).

Dorst, M.C., Tokarska, A., Zhou, M., Lee, K., Stagkourakis, S., Broberger, C., Masmanidis, S. and Silberberg, G. 2020. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nature Communications, 11, 5113.

Hjorth, J., Kozlov, A.K., Carannante, I., Frost-Nylén, J., Lindroos, R., Johansson, Y., Tokarska, A., Dorst, M.C., Suryanarayana, S.M., Silberberg, G., Hellgren Kotaleski, J., and Grillner, S. 2020. The microcircuits of striatum in silico. PNAS, 202000671,

Papathanou, M., Creed, M., Dorst, M.C., Bimpisidis, Z., Dumas, S., Pettersson, H., Bellone, C., Silberberg, G., Lüscher, C. and Wallén-Mackenzie, Å., 2018. Targeting VGLUT2 in mature dopamine neurons decreases mesoaccumbal glutamatergic transmission and identifies a role for glutamate co-release in synaptic plasticity by increasing baseline AMPA/NMDA ratio. Frontiers in neural circuits, 12, p.64.

Lindroos, R., Dorst, M.C., Du, K., Filipović, M., Keller, D., Ketzef, M., Kozlov, A.K., Kumar, A., Lindahl, M., Nair, A.G. and Pérez-Fernández, J., 2018. Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales—Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4. 2. Frontiers in neural circuits, 12, p.3.

Garas, F.N., Shah, R.S., Kormann, E., Doig, N.M., Vinciati, F., Nakamura, K.C., Dorst, M.C., Smith, Y., Magill, P.J. and Sharott, A., 2016. Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons. Elife, 5, p.e16088.
Last updated: 2022-08-10.